Correlation of serum Ang-1 and YKL-40 levels with coagulation function and inflam-matory response in patients with Kawasaki's disease complicated with coronary artery lesion
10.20039/j.cnki.1007-3949.2024.05.008
- VernacularTitle:川崎病合并冠状动脉病变患者血清Ang-1、YKL-40水平与凝血功能、炎症反应的相关性
- Author:
Zhen WANG
1
;
Shuai ZHANG
;
Zhe XU
Author Information
1. 郑州大学附属儿童医院输血科,河南省郑州市 450053
- Keywords:
Kawasaki's disease;
coronary artery lesion;
angiopoietin-1;
human cartilage glycoprotein-39;
coagulation function;
inflammatory response
- From:
Chinese Journal of Arteriosclerosis
2024;32(5):424-428
- CountryChina
- Language:Chinese
-
Abstract:
Aim To explore the correlation of serum angiopoietin-1(Ang-1)and human cartilage glycoprotein-39(YKL-40)levels with coagulation function and inflammatory response in patients with Kawasaki's disease(KD)compli-cated with coronary artery lesion(CAL).Methods From January 2018 to December 2022,90 children with KD were selected as the study subjects,and 90 healthy children who were examined in this hospital during the same period were selected as the control group.According to whether CAL was combined,they were divided into non-CAL group(69 cases)and CAL group(21 cases),the levels of serum Ang-1,YKL-40,coagulation function,and inflammatory factors were compared between the two groups.Pearson analysis was used to investigate the relationship between serum Ang-1,YKL-40 levels and coagulation function,inflammatory reaction indicators in children with KD combined with CAL.Multi-variate Logistic regression analysis was used to identify the factors affecting CAL in children with KD.Results There were significant differences in serum Ang-1 and YKL-40 levels among the control group,the non-CAL group and the CAL group(all P＜0.05).With the increase of the severity of the disease,the serum Ang-1 level in the control group,the non-CAL group and the CAL group decreased gradually,and the YKL-40 level increased gradually(all P＜0.05).Serum Ang-1 was negatively correlated with fibrinogen(FIB),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),in-terleukin-6(IL-6)and white blood cell count(WBC)(all P＜0.05),YKL-40 was positively correlated with FIB,CRP,TNF-α,IL-6 and WBC(all P＜0.05).Multivariate Logistic regression analysis showed that YKL-40 was a risk factor for CAL in children with KD,and Ang-1 was a protective factor(P＜0.05).Conclusion The level of serum Ang-1 de-creased and the level of YKL-40 increased in children with KD complicated with CAL,which was correlated with coagula-tion function and inflammatory response.
