Exploring the causal association between testosterone and atherosclerosis based on a two-sample Mendelian randomization analysis
10.20039/j.cnki.1007-3949.2024.04.009
- VernacularTitle:基于两样本孟德尔随机化方法探讨血清睾酮水平与动脉粥样硬化的因果关联
- Author:
Jiayi HU
1
,
2
;
Hongcen LIU
;
Shenglan GONG
;
Tian XIE
;
Tianfeng ZHANG
Author Information
1. 广州中医药大学深圳医院(福田)心血管病科,广东省深圳市 518034
2. 广州中医药大学第六临床医学院,广东省深圳市 518034
- Keywords:
Mendelian randomization study;
atherosclerosis;
testosterone;
causality
- From:
Chinese Journal of Arteriosclerosis
2024;32(4):339-346
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study whether genetically predicted serum testosterone level is causally associated with sys-temic multisite atherosclerosis.Methods Based on two pooled databases of genome-wide association studies on testos-terone and atherosclerosis in European populations from two separate foreign countries,the causal effect between testosterone and atherosclerosis was assessed using two-sample Mendelian randomization analysis with data on testosterone-associated genetic variants as instrumental variables(Ⅳ),and by using the inverse-variance weighted(IVW)method,MR-Egger regression,and weighted median estimation.Results IVW results showed that genetically predicted circu-lating testosterone levels were negatively associated with the risk of peripheral atherosclerosis(OR=0.93,95％CI:0.86～1.00,P=0.01),and that elevated testosterone level may reduce the risk of developing peripheral atherosclerosis,while no evidence of a potential causal association was found with cerebral atherosclerosis,coronary atherosclerosis and other athero-sclerosis type(P＞O.05).Conclusion The final analysis showed a causal relationship between genetically predicted testosterone level and the risk of developing peripheral atherosclerosis,and the role of testosterone therapy in the prevention and treatment of atherosclerosis deserves attention and further study.
