Research progress on the role of N6-methyladenosine modification in atherosclerosis and drug intervention
10.20039/j.cnki.1007-3949.2024.04.001
- VernacularTitle:N6-甲基腺苷修饰在动脉粥样硬化中的作用及药物干预的研究进展
- Author:
Xiaolu ZHANG
1
;
Miaoying GENG
;
Yun WANG
;
Shengyong MENG
;
Yijing WANG
;
Xijuan JIANG
Author Information
1. 天津中医药大学,天津市 301617
- Keywords:
atherosclerosis;
N6-methyladenosine modification;
methyltransferases;
demethylases;
drug intervention
- From:
Chinese Journal of Arteriosclerosis
2024;32(4):277-284
- CountryChina
- Language:Chinese
-
Abstract:
N6-methyladenosine(m6A)modification is one of the most abundant epitranscriptomic modifications in eukaryotic mRNA,with dynamic and reversible properties.This modification process is coordinated by methyltransferases,demethylases,and related m6A binding proteins,which in turn affect mRNA metabolism and function.Increasing evi-dence has indicated that the m6A RNA modification plays an important role in the occurrence and development of athero-sclerosis(As)and other related diseases.This paper provide a comprehensive review of the relationship between m6A RNA modification and As.The entire manuscript summarizes the m6A RNA modification mechanism and its roles in As-related cells including endothelial cells,macrophages,and smooth muscle cells,and discusses the association of m6A RNA modification with risk factors of As such as high-fat diet,ischemia/hypoxia,oscillatory stress,and hypertension.Finally,this review summarizes researches on drug intervention targeting m6A RNA methylation to mitigate As.These studies pro-vide important references for exploring new targets for early diagnosis and treatment of As.
