Macrophage ferroptosis and atherosclerosis

VernacularTitle:巨噬细胞铁死亡与动脉粥样硬化
Author: Qiong WANG ^{1
,

2} ; Anni FENG ; Houdi YA ; Yuhua CHEN ; Biao ZHENG ; Zhongcheng MO
Author Information

1. 广西糖尿病系统医学重点实验室桂林医学院组织学与胚胎学教研室,广西桂林市 541199
2. 桂林医学院-明舜制药慢性病防治研究联合实验室,湖南省邵阳市 422800
Keywords: macrophage; ferroptosis; atherosclerosis; lipid peroxidation; oxidative stress
From: Chinese Journal of Arteriosclerosis 2024;32(3):257-262
CountryChina
Language:Chinese
Abstract: Atherosclerosis is the pathological basis of a variety of cardiovascular diseases,which are still the leading cause of human death worldwide.Ferroptosis is a kind of iron dependent non-apoptotic cell death mode,which is closely related to various physiological mechanisms.Recent studies have found that ferroptosis in macrophages plays an important role in the occurrence and development of atherosclerosis.Based on the imbalance of iron metabolism in macrophages,this paper reviews the correlation between ferroptosis in macrophages and atherosclerosis in terms of the interaction between ferroptosis in macrophages and lipid peroxidation,inflammation,oxidative stress,etc.,in order to provide new ideas for the study of the pathogenesis of atherosclerosis.