Research progress on the immune regulatory effect of myeloid derived suppressor cells on parasitic infections

VernacularTitle:髓源性抑制细胞对寄生虫感染的免疫调控作用研究进展
Author: Haiting XIONG ¹ ; Biying ZHOU
Author Information

1. 贵州省遵义医科大学寄生虫学教研室，遵义　563000
Keywords: Parasites; Myeloid derived suppressor cell; T cell; Immune regulation
From: Chinese Journal of Endemiology 2024;43(11):937-941
CountryChina
Language:Chinese
Abstract: Myeloid derived suppressor cells (MDSCs) are a type of immature, differentiated, heterogeneous cells derived from the bone marrow. MDSC plays a dual role in parasitic infections. On the one hand, the cells can induce helper T cell 1/2 (Th1/Th2) immune responses by inducing host secretion of interferon-γ (IFN-γ), interleukin (IL)-4, and IL-13. On the other hand, they can also secrete IL-10, IL-17 and transforming growth factor-β (TGF-β) to induce regulatory T cells (Treg)/Th17 immune responses, thereby exerting immune protection or immune escape. This article provides a review of the research progress on the immune regulation of host T cells by MDSC in parasitic infections.