Research progress on the mechanism of cartilage damage induced by matrix metalloproteinase in Kashin-Beck disease

VernacularTitle:基质金属蛋白酶致大骨节病软骨损伤机制的研究进展
Author: Xinke ZHU ¹ ; Kun ZUO ; Zhengming SUN ; Xueyuan WU
Author Information

1. 西安医学院研究生院，西安　710021
Keywords: Kashin-Beck disease; Matrix metalloproteinase; Cartilage degradation; Genetic polymorphism
From: Chinese Journal of Endemiology 2024;43(8):678-682
CountryChina
Language:Chinese
Abstract: Kashin-Beck disease (KBD) is a chronic endemic bone and joint disease, with severe cases of short stature, joint deformities, and significantly reduced quality of life. Its etiology is currently unclear. Matrix metalloproteinases (MMPs) are endopeptidases that can degrade the extracellular matrix of articular cartilage cells, and are closely related to the occurrence and development of bone and joint diseases. At present, some scholars have found that MMPs can cause cartilage damage in KBD patients and promote the progression of KBD, but its specific mechanism of action is still unclear. This article reviews the research progress on the etiology of KBD, MMPs and its related genes, and their relationship with KBD cartilage injury both domestically and internationally. In order to provide theoretical support for in-depth research on the pathogenesis of KBD and to improve and update its treatment methods.