Anti-Helicobacter pylori activities of FEMY-R7 composed of fucoidan and evening primrose extract in mice and humans.
10.5625/lar.2014.30.3.131
- Author:
Tae Su KIM
1
;
Ehn Kyoung CHOI
;
Jihyun KIM
;
Kyungha SHIN
;
Sung Pyo LEE
;
Youngjin CHOI
;
Joseph H JEON
;
Yun Bae KIM
Author Information
1. Misuba RTech Co., Ltd., Asan, Korea.
- Publication Type:Letter
- Keywords:
Helicobacter pylori;
FEMY-R7;
fucoidan;
evening primrose extract;
Campylobcter-like organism-detection test;
urea breath test;
pepsinogen
- MeSH:
Animals;
Bacteria;
Breath Tests;
Gastric Mucosa;
Helicobacter;
Helicobacter pylori;
Humans;
Male;
Mice*;
Oenothera biennis*;
Pepsinogen A;
Pepsinogens;
Urea
- From:Laboratory Animal Research
2014;30(3):131-135
- CountryRepublic of Korea
- Language:English
-
Abstract:
Helicobacter pylori-eliminating effects of FEMY-R7, composed of fucoidan and evening primrose extract, were investigated in mice and humans. Male C57BL/6 mice were infected with the bacteria by intragastric inoculation (1x10(9) CFU/mouse) 3 times at 2-day intervals, and simultaneously, orally treated twice a day with 10 or 100 mg/kg FEMY-R7 for 2 weeks. In Campylobcter-like organism-detection test, FEMY-R7 markedly reduced the urease-positive reactivity. In a clinical sudy, human subjects, confirmed to be infected with Helicobacter pylori, were orally administered twice a day with a capsule containing 150 mg FEMY-R7 for 8 weeks. FEMY-R7 significantly decreased both the Delta over baseline-value in urea breath test and the serum pepsinogens I and II levels. The results indicate that FEMY-R7 not only eliminates H. pylori from gastric mucosa of animals and humans, but also improves gastric function.
