Meta-analysis of the relationship between maternal arsenic exposure during pregnancy and newborn birth indicators
10.3760/cma.j.cn231583-20230306-00046
- VernacularTitle:母体孕期砷暴露与新生儿出生指标关系的Meta分析
- Author:
Keyan MIAO
1
;
Weici LIU
;
Nan JING
;
Qianlei YANG
;
Yan AN
Author Information
1. 苏州大学苏州医学院，苏州 215000
- Keywords:
Arsenic;
Newborn;
Exposure during pregnancy;
Birth indicators;
Meta-analysis
- From:
Chinese Journal of Endemiology
2024;43(6):502-512
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To systematically evaluate the impact of maternal arsenic exposure during pregnancy on newborn birth indicators.Methods:Relevant literature on maternal arsenic exposure during pregnancy and newborn birth indicators published domestically and internationally were included in the study by searching databases such as CNKI, WanFang Data, VIP, PubMed, Web of Science, Embase, etc., the search was conducted from the establishment of the database until August 31, 2022. Meta-analysis of effect values was performed using Stata SE16 software, and heterogeneity was tested using I2 statistics and Q-test. Random effects model or a fixed effects model was selected for comprehensive quantitative analysis based on the test results, and regression coefficient (β) was used as the effect indicator. Subgroup analysis was conducted according to the sample type, study area, study type. Results:A total of 34 articles (a total of 57 530 pairs of maternal infant combinations) were included, including 2 Chinese articles and 32 English articles. Among them, there were 31, 16, 18, and 5 articles including maternal arsenic exposure during pregnancy and newborn birth weight, length, head circumference, and chest circumference, respectively. After heterogeneity testing, I2 were 81.1%, 97.1%, 62.8%, and 98.3%, respectively. I2 was ≥50% and P < 0.05, indicating significant heterogeneity. A random effects model was used for meta-analysis. The combined β values (95% CI) of birth weight, length, head circumference, and chest circumference were - 10.99 (- 15.60, - 6.39), - 0.02 ( - 0.10, 0.06), - 0.01 (- 0.04, 0.03), and - 0.18 (- 0.35, - 0.01), respectively. The results of subgroup analysis showed that maternal arsenic exposure during pregnancy had a significant impact on newborn birth weight when the sample type was the blood sample [β(95% CI): - 25.72 (- 44.46, - 6.98)]. Conclusions:Maternal arsenic exposure during pregnancy may cause a relative decrease in newborn birth indicators, especially a significant decrease in birth weight. Blood arsenic level may be an important indicator for evaluating the decrease in birth indicators caused by maternal arsenic exposure during pregnancy.
