Clinical characteristics and nutritional status of children with Crohn's disease and risk factors for malnutrition
10.7499/j.issn.1008-8830.2407056
- VernacularTitle:儿童克罗恩病营养状况与临床特征及危险因素分析
- Author:
Dong-Dan LI
1
;
Xiao-Lin YE
;
Mei-Chen WANG
;
Hong-Mei HUANG
;
Jie YAN
;
Tian-Zhuo ZHANG
;
Fei-Hong YU
;
De-Xiu GUAN
;
Wen-Li YANG
;
Lu-Lu XIA
;
Jie WU
Author Information
1. 国家儿童医学中心/首都医科大学附属北京儿童医院临床营养科,北京 100045
- Keywords:
Crohn's disease;
Malnutrition;
Child
- From:
Chinese Journal of Contemporary Pediatrics
2024;26(11):1194-1201
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the nutritional status of children with Crohn's Disease (CD) at diagnosis and its association with clinical characteristics. Methods A retrospective analysis was performed for the clinical data and nutritional status of 118 children with CD who were admitted to Beijing Children's Hospital,Capital Medical University,from January 2016 to January 2024. A multivariate logistic regression analysis was used to investigate the risk factors for malnutrition. Results A total of 118 children with CD were included,among whom there were 68 boys (57.6％) and 50 girls (42.4％),with a mean age of (11±4) years. Clinical symptoms mainly included recurrent abdominal pain (73.7％,87/118),diarrhea (37.3％,44/118),and hematochezia (32.2％,38/118),and 63.6％ (75/118) of the children had weight loss at diagnosis. The incidence rate of malnutrition was 63.6％ (75/118),and the children with moderate or severe malnutrition accounted for 67％ (50/75). There were 50 children (42.4％) with emaciation,8 (6.8％) with growth retardation,and 9 (7.6％) with overweight or obesity. Measurement of nutritional indices showed a reduction in serum albumin in 83 children (70.3％),anemia in 74 children (62.7％),and a reduction in 25 hydroxyvitamin D in 15 children (60％,15/25). The children with malnutrition had significantly higher disease activity,proportion of children with intestinal stenosis,and erythrocyte sedimentation rate and a significant reduction in serum albumin (P<0.05). The multivariate logistic regression analysis showed that intestinal stenosis was an independent risk factor for malnutrition in children with CD (OR=4.416,P<0.05). Conclusions There is a high incidence rate of malnutrition in children with CD at diagnosis,which is associated with disease activity and disease behavior. The nutritional status of children with CD should be closely monitored.
