Advances in the treatment of Clostridium difficile infection in children
10.7499/j.issn.1008-8830.2405055
- VernacularTitle:儿童艰难梭菌感染的治疗进展
- Author:
Yu GAN
1
;
Zhi-Hong WU
;
Qian-Long LI
;
Zhao-Xia LU
;
Lin-Lin CHEN
Author Information
1. 川北医学院,四川南充 637000
- Keywords:
Clostridium difficile infection;
Treatment;
Fecal microbiota transplantation;
Child
- From:
Chinese Journal of Contemporary Pediatrics
2024;26(9):995-1001
- CountryChina
- Language:Chinese
-
Abstract:
Clostridium difficile infection(CDI)is a major cause of hospital-acquired gastrointestinal infections in children.Current treatment for pediatric CDI primarily involves antibiotics;however,some children experience recurrence after antibiotic treatment,and those with initial recurrence remain at risk for further recurrences following subsequent antibiotic therapy.In such cases,careful consideration of treatment options is necessary.Fecal microbiota transplantation has been shown to be effective for recurrent CDI and has a high safety profile.This article reviews the latest research on the pathogenesis,risk factors,diagnosis,and treatment of pediatric CDI domestically and internationally,with a particular focus on fecal microbiota transplantation therapy.
