Correlation of anti-C1q antibodies with active systemic lupus erythematosus and lupus nephritis in children
10.7499/j.issn.1008-8830.2404159
- VernacularTitle:抗C1q抗体与儿童活动性系统性红斑狼疮和活动性狼疮性肾炎的相关性分析
- Author:
Yong-Zhen LI
1
;
Jin-Rong YANG
;
Yu-Di ZHANG
;
Yan CAO
;
Xiao-Yan LI
;
Lan-Jun SHUAI
;
Ying WANG
;
Tian SHEN
;
Xiao-Chuan WU
Author Information
1. 中南大学湘雅二医院儿童医学中心,湖南长沙 410000
- Keywords:
Systemic lupus erythematosus;
Lupus nephritis;
Anti-C1q antibody;
Activity;
Child
- From:
Chinese Journal of Contemporary Pediatrics
2024;26(8):835-839
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation of anti-C1q antibodies with active systemic lupus erythematosus(SLE)and lupus nephritis(LN)in children,as well as their diagnostic value for active SLE and LN.Methods A retrospective selection of 90 hospitalized children with SLE at the Children's Medical Center of Second Xiangya Hospital,Central South University from January 2016 to March 2019 as the SLE group,all of whom were tested for anti-C1q antibodies.A control group was formed by collecting 70 hospitalized children with other autoimmune diseases(OAD)during the same period.The differences in anti-C1q antibody levels were compared between two groups.The correlation of anti-C1q antibodies with various indicators of SLE and LN was analyzed,and the diagnostic value of anti-C1q in SLE and LN was evaluated.Results The serum levels of anti-C1q antibodies in the SLE group were higher than those in the OAD group(P<0.05).The SLE disease activity index score was positively correlated with anti-C1q antibodies(rs=0.371,P<0.001)and positively correlated with anti-double-stranded DNA antibodies(rs=0.370,P<0.001).The sensitivity and specificity of anti-C1q antibodies for diagnosing active SLE were 89.90%and 53.90%,respectively,with an area under the curve of 0.720(P<0.05)and a critical value of 5.45 U/mL.The sensitivity and specificity of anti-C1q antibody levels for diagnosing active LN were 58.50%and 85.00%,respectively,with an area under the curve of 0.675(P<0.05)and a critical value of 22.05 U/mL.Conclusions Anti-C1q antibodies can serve as non-invasive biomarkers for evaluating the activity of SLE or predicting the activity of LN in children.
