Investigation of influencing factors and reference ranges for thyroid function in hospitalized preterm infants at the age of 7 days
10.7499/j.issn.1008-8830.2312151
- VernacularTitle:7日龄住院早产儿甲状腺功能影响因素及参考值范围探讨
- Author:
Jiao QI
1
;
Xi-Yu HE
Author Information
1. 解放军总医院第五医学中心儿科,北京 100070
- Keywords:
Thyroid function;
Influencing factor;
Reference range;
Gestational age;
Preterm infant
- From:
Chinese Journal of Contemporary Pediatrics
2024;26(6):625-630
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influencing factors and reference ranges for thyroid function in preterm infants at the age of 7 days,with the aim of avoiding unnecessary clinical reexamination and intervention.Methods A retrospective analysis was performed for the data of 685 preterm infants from January 2020 to January 2023.According to gestational age and birth weight,they were divided into a high-risk group(gestational age<34 weeks or birth weight<2 000 g;228 infants)and a low-risk group(gestational age≥34 weeks and birth weight≥2 000 g;457 infants).The influencing factors for thyroid function were analyzed,and 95%reference range was calculated.Results Gestational age,birth weight,birth season,sex,and assisted reproduction were the influencing factors for thyroid function(P<0.05).For the preterm infants in the high-risk group,the reference ranges of free triiodothyronine(FT3),free thyroxine(FT4),total triiodothyronine(TT3),total thyroxine(TT4),and thyroid stimulating hormone(TSH)were 2.79-5.40 pmol/L,8.80-25.64 pmol/L,0.80-2.15 nmol/L,50.06-165.09 nmol/L,and 0.80-18.57 μIU/mL,respectively.For those in the low-risk group,the reference ranges of these indicators were 3.08-5.93 pmol/L,11.17-26.24 pmol/L,1.02-2.27 nmol/L,62.90-168.95 nmol/L,and 0.69-13.70 μIU/mL,respectively.FT3,FT4,TT3,and TT4 were positively correlated with gestational age(P<0.05);FT3,FT4,TT3,and TT4 were positively correlated with birth weight(P<0.05);TSH was negatively correlated with birth weight(P<0.05).Conclusions Thyroid function in preterm infants at the age of 7 days is affected by the factors such as gestational age and birth weight,and the reference ranges of thyroid function in preterm infants at the age of 7 days should be established based on gestational age and birth weight.
