Risk factors for bronchopulmonary dysplasia in twin preterm infants:a multicenter study
10.7499/j.issn.1008-8830.2312005
- VernacularTitle:双胎早产儿支气管肺发育不良危险因素分析:一项多中心研究
- Author:
Yu-Wei FAN
1
;
Yi-Jia ZHANG
;
He-Mei WEN
;
Hong YAN
;
Wei SHEN
;
Yue-Qin DING
;
Yun-Feng LONG
;
Zhi-Gang ZHANG
;
Gui-Fang LI
;
Hong JIANG
;
Hong-Ping RAO
;
Jian-Wu QIU
;
Xian WEI
;
Ya-Yu ZHANG
;
Ji-Bin ZENG
;
Chang-Liang ZHAO
;
Wei-Peng XU
;
Fan WANG
;
Li YUAN
;
Xiu-Fang YANG
;
Wei LI
;
Ni-Yang LIN
;
Qian CHEN
;
Chang-Shun XIA
;
Xin-Qi ZHONG
;
Qi-Liang CUI
Author Information
1. 广州医科大学附属第三医院新生儿科/广东省产科重大疾病重点实验室/广东省妇产疾病临床医学研究中心/粤港澳母胎医学高校联合实验室,广东广州 510150
- Keywords:
Bronchopulmonary dysplasia;
Risk factor;
Multicenter study;
Twins;
Preterm infant
- From:
Chinese Journal of Contemporary Pediatrics
2024;26(6):611-618
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the risk factors for bronchopulmonary dysplasia(BPD)in twin preterm infants with a gestational age of<34 weeks,and to provide a basis for early identification of BPD in twin preterm infants in clinical practice.Methods A retrospective analysis was performed for the twin preterm infants with a gestational age of<34 weeks who were admitted to 22 hospitals nationwide from January 2018 to December 2020.According to their conditions,they were divided into group A(both twins had BPD),group B(only one twin had BPD),and group C(neither twin had BPD).The risk factors for BPD in twin preterm infants were analyzed.Further analysis was conducted on group B to investigate the postnatal risk factors for BPD within twins.Results A total of 904 pairs of twins with a gestational age of<34 weeks were included in this study.The multivariate logistic regression analysis showed that compared with group C,birth weight discordance of>25%between the twins was an independent risk factor for BPD in one of the twins(OR=3.370,95%CI:1.500-7.568,P<0.05),and high gestational age at birth was a protective factor against BPD(P<0.05).The conditional logistic regression analysis of group B showed that small-for-gestational-age(SGA)birth was an independent risk factor for BPD in individual twins(OR=5.017,95%CI:1.040-24.190,P<0.05).Conclusions The development of BPD in twin preterm infants is associated with gestational age,birth weight discordance between the twins,and SGA birth.
