Neurodevelopment and cerebral blood flow in children aged 2-6 years with autism spectrum disorder
10.7499/j.issn.1008-8830.2401048
- VernacularTitle:2～6岁孤独症谱系障碍儿童神经发育与脑血流量的研究
- Author:
Jia-Bao YIN
1
;
Gan-Yu WANG
;
Gui-Qin DUAN
;
Wen-Hao NIE
;
Ming-Fang ZHAO
;
Ting-Ting JIN
Author Information
1. 郑州大学第三附属医院儿童保健科/儿童发育行为科,河南郑州 450052
- Keywords:
Autism spectrum disorder;
Developmental quotient;
Cerebral blood flow;
Arterial spin labeling;
Child
- From:
Chinese Journal of Contemporary Pediatrics
2024;26(6):599-604
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the neurodevelopmental characteristics of children with autism spectrum disorder(ASD),analyze the correlation between neurodevelopmental indicators and cerebral blood flow(CBF),and explore the potential mechanisms of neurodevelopment in ASD children.Methods A retrospective study was conducted on 145 children aged 2-6 years with newly-diagnosed ASD.Scores from the Gesell Developmental Diagnosis Scale and the Autism Behavior Checklist(ABC)and CBF results were collected to compare gender differences in the development of children with ASD and analyze the correlation between CBF and neurodevelopmental indicators.Results Fine motor and personal-social development quotient in boys with ASD were lower than those in girls with ASD(P<0.05).Gross motor development quotient in ASD children was negatively correlated with CBF in the left frontal lobe(r=-0.200,P=0.016),right frontal lobe(r=-0.279,P=0.001),left parietal lobe(r=-0.208,P=0.012),and right parietal lobe(r=-0.187,P=0.025).The total ABC score was positively correlated with CBF in the left amygdala(r=0.295,P<0.001).Conclusions Early intervention training should pay attention to gender and developmental structural characteristics for precise intervention in ASD children.CBF has the potential to become a biological marker for assessing the severity of ASD.
