Efficacy and safety of dust mite subcutaneous immunotherapy in children with allergic asthma:a prospective randomized controlled study
10.7499/j.issn.1008-8830.2309137
- VernacularTitle:尘螨皮下免疫治疗应用于儿童过敏性哮喘疗效
- Author:
Ya-Ni WANG
1
;
Si-Qi LU
;
Hai CHEN
;
Yu-Qin LI
;
Hong-Yan LU
;
Hui ZHU
;
Ming CHANG
Author Information
1. 江苏大学附属医院儿科,江苏镇江 212001
- Keywords:
Subcutaneous immunotherapy;
Allergic asthma;
Efficacy;
Safety;
Child
- From:
Chinese Journal of Contemporary Pediatrics
2024;26(6):559-566
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy and safety of subcutaneous immunotherapy(SCIT)using dust mites in children with allergic asthma.Methods In a prospective randomized controlled study,98 children with dust mite-induced allergic asthma were randomly divided into a control group(n=49)and an SCIT group(n=49).The control group received inhaled corticosteroid treatment,while the SCIT group additionally received a standardized three-year SCIT regimen.The two groups were compared based on peripheral blood eosinophil percentage,visual analogue score(VAS),total medication score,Asthma Control Test/Childhood Asthma Control Test scores,fractional exhaled nitric oxide(FeNO),and lung function before treatment,and at 6 months,1 year,2 years,and 3 years after treatment.Adverse reactions were recorded post-injection to evaluate the safety of SCIT.Results Compared with pre-treatment levels,the SCIT group showed a significant reduction in the percentage of peripheral blood eosinophils,VAS,total medication score,and FeNO,while lung function significantly improved,and asthma control levels were better 3 years after treatment(P<0.05).Compared with the control group,the SCIT group showed more significant improvement in all evaluated indicators 3 years after treatment(P<0.05).A total of 2 744 injections were administered,resulting in 157 cases(5.72%)of local adverse reactions and 4 cases(0.15%)of systemic adverse reactions,with no severe systemic adverse events.Conclusions SCIT is an effective and safe treatment for allergic asthma in children.
