A multicenter study of neonatal stroke in Shenzhen,China
- VernacularTitle:深圳市新生儿脑卒中多中心现况调查
- Author:
Li-Xiu SHI
1
;
Jin-Xing FENG
;
Yan-Fang WEI
;
Xin-Ru LU
;
Yu-Xi ZHANG
;
Lin-Ying YANG
;
Sheng-Nan HE
;
Pei-Juan CHEN
;
Jing HAN
;
Cheng CHEN
;
Hui-Ying TU
;
Zhang-Bin YU
;
Jin-Jie HUANG
;
Shu-Juan ZENG
;
Wan-Ling CHEN
;
Ying LIU
;
Yan-Ping GUO
;
Jiao-Yu MAO
;
Xiao-Dong LI
;
Qian-Shen ZHANG
;
Zhi-Li XIE
;
Mei-Ying HUANG
;
Kun-Shan YAN
;
Er-Ya YING
;
Jun CHEN
;
Yan-Rong WANG
;
Ya-Ping LIU
;
Bo SONG
;
Hua-Yan LIU
;
Xiao-Dong XIAO
;
Hong TANG
;
Yu-Na WANG
;
Yin-Sha CAI
;
Qi LONG
;
Han-Qiang XU
;
Hui-Zhan WANG
;
Qian SUN
;
Fang HAN
;
Rui-Biao ZHANG
;
Chuan-Zhong YANG
;
Lei DOU
;
Hui-Ju SHI
;
Rui WANG
;
Ping JIANG
;
Shenzhen Neonatal Data Network
Author Information
- Keywords: Stroke; Multicenter study; Neonate
- From: Chinese Journal of Contemporary Pediatrics 2024;26(5):450-455
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the incidence rate,clinical characteristics,and prognosis of neonatal stroke in Shenzhen,China.Methods Led by Shenzhen Children's Hospital,the Shenzhen Neonatal Data Collaboration Network organized 21 institutions to collect 36 cases of neonatal stroke from January 2020 to December 2022.The incidence,clinical characteristics,treatment,and prognosis of neonatal stroke in Shenzhen were analyzed.Results The incidence rate of neonatal stroke in 21 hospitals from 2020 to 2022 was 1/15 137,1/6 060,and 1/7 704,respectively.Ischemic stroke accounted for 75％(27/36);boys accounted for 64％(23/36).Among the 36 neonates,31(86％)had disease onset within 3 days after birth,and 19(53％)had convulsion as the initial presentation.Cerebral MRI showed that 22 neonates(61％)had left cerebral infarction and 13(36％)had basal ganglia infarction.Magnetic resonance angiography was performed for 12 neonates,among whom 9(75％)had involvement of the middle cerebral artery.Electroencephalography was performed for 29 neonates,with sharp waves in 21 neonates(72％)and seizures in 10 neonates(34％).Symptomatic/supportive treatment varied across different hospitals.Neonatal Behavioral Neurological Assessment was performed for 12 neonates(33％,12/36),with a mean score of(32±4)points.The prognosis of 27 neonates was followed up to around 12 months of age,with 44％(12/27)of the neonates having a good prognosis.Conclusions Ischemic stroke is the main type of neonatal stroke,often with convulsions as the initial presentation,involvement of the middle cerebral artery,sharp waves on electroencephalography,and a relatively low neurodevelopment score.Symptomatic/supportive treatment is the main treatment method,and some neonates tend to have a poor prognosis.
