Cerebral oxygen metabolism and brain electrical activity of healthy full-term neonates in high-altitude areas:a multicenter clinical research protocol
10.7499/j.issn.1008-8830.2310102
- VernacularTitle:高海拔地区健康足月新生儿脑氧代谢及脑电活动差异的多中心临床研究方案
- Author:
Bi ZE
1
;
Jin GAO
;
Xiao-Fen ZHAO
;
Yang-Fang LI
;
Tie-Song ZHANG
;
Xiao-Mei LIU
;
Hui MAO
;
Ming-Cai QIN
;
Yi ZHANG
;
Yong-Li YANG
;
Chun-Ye HE
;
Yan ZHAO
;
Kun DU
;
Lin LIU
;
Wen-Hao ZHOU
;
Chinese High Altitude Neonatal Medicine Alliance
Author Information
1. 国家儿童医学中心/复旦大学附属儿科医院新生儿科,上海 201101
- Keywords:
Near-infrared spectroscopy;
Cerebral oxygenation;
Amplitude-integrated electroencephalography;
High altitude;
Neonate
- From:
Chinese Journal of Contemporary Pediatrics
2024;26(4):403-409
- CountryChina
- Language:Chinese
-
Abstract:
Further evidence is needed to explore the impact of high-altitude environments on the neurologic function of neonates.Non-invasive techniques such as cerebral near-infrared spectroscopy and amplitude-integrated electroencephalography can provide data on cerebral oxygenation and brain electrical activity.This study will conduct multiple cerebral near-infrared spectroscopy and amplitude-integrated electroencephalography monitoring sessions at various time points within the first 3 days postpartum for healthy full-term neonates at different altitudes.The obtained data on cerebral oxygenation and brain electrical activity will be compared between different altitudes,and corresponding reference ranges will be established.The study involves 6 participating centers in the Chinese High Altitude Neonatal Medicine Alliance,with altitude gradients divided into 4 categories:800 m,1 900 m,2 400 m,and 3 500 m,with an anticipated sample size of 170 neonates per altitude gradient.This multicenter prospective cohort study aims to provide evidence supporting the impact of high-altitude environments on early brain function and metabolism in neonates.[Chinese Journal of Contemporary Pediatrics,2024,26(4):403-409]
