Clinical study on growth impairment induced by oral glucocorticoids based on FGF23/Klotho homeostasis observations
10.7499/j.issn.1008-8830.2309160
- VernacularTitle:基于FGF23/Klotho稳态观察口服糖皮质激素致生长障碍的临床研究
- Author:
Shuai TANG
1
;
Yang YANG
;
Xiang LI
;
Bing-Yang BIE
;
Jian ZHANG
Author Information
1. 河南中医药大学儿科医学院,河南郑州 450000
- Keywords:
Primary nephrotic syndrome;
Glucocorticosteroid;
Growth impairment;
FGF23;
Klotho;
Child
- From:
Chinese Journal of Contemporary Pediatrics
2024;26(3):269-274
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the correlation between growth impairment induced by long-term oral glucocorticoids(GC)therapy and the ratio of FGF23/Klotho in children with primary nephrotic syndrome(PNS).Methods A prospective study was conducted on 56 children with GC-sensitive PNS who had discontinued GC therapy for more than 3 months and revisited the Department of Pediatrics of the First Affiliated Hospital of Henan University of Traditional Chinese Medicine between June 2022 and December 2022.After monitoring qualitative and quantitative urine protein levels upon admission,the children with proteinuria relapse were treated with GC(GC group;n=29),while those without relapse did not receive GC treatment(non-GC group;n=27).In addition,29 healthy children aged 3 to prepuberty were selected as the control group.Height,bone age,growth rate,and the FGF23/Klotho ratio were compared among the groups.The correlations of the FGF23/Klotho ratio with height,bone age,and growth rate were analyzed.Results The FGF23/Klotho ratio in the GC group was significantly higher than that in the non-GC group after 1 month of GC therapy(P＜0.05),and the height and bone age growth rates within 6 months were lower than those in the non-GC group(P＜0.05).Correlation analysis showed significant negative correlations between the FGF23/Klotho ratio after 1 month of treatment and the growth rates of height and bone age within 6 months in children with PNS(r=-0.356 and-0.436,respectively;P＜0.05).Conclusions The disturbance in FGF23/Klotho homeostasis is one of the mechanisms underlying the growth impairment caused by long-term oral GC therapy.[Chinese Journal of Contemporary Pediatrics,2024,26(3):269-2741
