Risk factors for cow's milk protein allergy in infants:a multicenter prospective nested case-control study
10.7499/j.issn.1008-8830.2309105
- VernacularTitle:婴儿牛奶蛋白过敏的危险因素:一项多中心前瞻性巢式病例对照研究
- Author:
Lin HOU
1
;
Zi-Jun MA
;
Shuang CHAO
;
Zhong-Yuan LI
;
Yu ZHANG
;
Yi-Jian LIU
;
Jun-Hong ZHANG
;
Wen-Yan WU
;
Jie LIU
Author Information
1. 北京大学人民医院儿科,北京 100044
- Keywords:
Cow's milk protein allergy;
Risk factor;
Food allergy;
Infant
- From:
Chinese Journal of Contemporary Pediatrics
2024;26(3):230-235
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the risk factors associated with cow's milk protein allergy(CMPA)in infants.Methods This study was a multicenter prospective nested case-control study conducted in seven medical centers in Beijing,China.Infants aged 0-12 months were included,with 200 cases of CMPA infants and 799 control infants without CMPA.Univariate and multivariate logistic regression analyses were used to investigate the risk factors for the occurrence of CMPA.Results Univariate logistic regression analysis showed that preterm birth,low birth weight,birth from the first pregnancy,firstborn,spring birth,summer birth,mixed/artificial feeding,and parental history of allergic diseases were associated with an increased risk of CMPA in infants(P＜0.05).Multivariate logistic regression analysis revealed that firstborn(OR=1.89,95％CI:1.14-3.13),spring birth(OR=3.42,95％CI:1.70-6.58),summer birth(OR=2.29,95％CI:1.22-4.27),mixed/artificial feeding(OR=1.57,95％CI:1.10-2.26),parental history of allergies(OR=2.13,95％CI:1.51-3.02),and both parents having allergies(OR=3.15,95％CI:1.78-5.56)were risk factors for CMPA in infants(P＜0.05).Conclusions Firstborn,spring birth,summer birth,mixed/artificial feeding,and a family history of allergies are associated with an increased risk of CMPA in infants.[Chinese Journal of Contemporary Pediatrics,2024,26(3):230-235]
