Value of urine 8-iso-PGF2α in the assessment of the severity of neonatal hypoxic-ischemic encephalopathy
10.3969/j.issn.1008-8830.2005.02.003
- VernacularTitle:尿8-异前列腺素F2α测定在新生儿缺氧缺血性脑病病情评估中的价值
- Author:
CHEN LING-LING
1
;
XIAO XIN
;
XIONG AI-HUA
;
CHEN WEN-QING
;
ZHOU XIAO-GUANG
;
YE ZHEN-ZHI
Author Information
1. 暨南大学医学院附属第一医院(广州华侨医院)
- Keywords:
8-iso-PGF2α,urine;
Hypoxia-ischemia,brain;
Infant,newborn
- From:
Chinese Journal of Contemporary Pediatrics
2005;7(2):103-106
- CountryChina
- Language:Chinese
-
Abstract:
Objective It was aimed to determine the concentration of urine 8-iso-PGF2α in normal neonates and neonates with hypoxic-ischemic encephalopathy (HIE) and to study the value of urine 8-iso-PGF2α in the assessment of the severity of neonatal HIE. Methods Urine samples from normal (n = 126) and HIE ( n = 151 ) neonates were collected on the 1 st, 3rd and 7th days after birth. ELISA was used to determine the urine 8-iso-PGF2α contents. Results 1 ) Urine 8-and 7th days after birth, respectively. There was no significant difference among the three days for the urine 8-iso-PGF2α contents. 2) On the 1 st day of HIE onset, neonates with mild, moderate and severe HIE had higher levels of urine 8-isoneonates (P < 0. 001 ). 3 ) On the 3rd day, the urine 8-iso-PGF2α content in neonates with moderate and severe HIE while that of the neonates with mild HIE regressed to normal. 4) On the 7th day, there was no significant difference in the of urine 8-iso-PGF2α were defined to distinguish from normal to mild HIE, from mild to moderate HIE and from moderate to severe HIE. As defined, the corresponding sensitivity and specificity were 95.2% and 99.2%, 100% and 95.2%,65.8% and 100%. Conclusions The urine 8-iso-PGF2α levels in neonates were stable within 7 days after birth. The urine 8-iso-PGF2α contents in HIE neonates reached the peak within 24 hours after onset. There was a correlation between the urine 8-iso-PGF2α contents and the severity of HIE, suggesting that urine 8-iso-PGF2α may be a reliable and convenient index for the assessment of the severity of HIE.
