Changes of Maternal and Neonatal Plasma Prolactin Levels in Neonatal Asphyxia
10.3969/j.issn.1008-8830.2003.06.004
- VernacularTitle:新生儿窒息母儿血浆催乳素水平变化的研究
- Author:
LI ZHAN-KUI
1
;
FENG JIN-XING
;
DUAN ZHAO
;
Liu MING
;
LIU YA
;
LI JING
;
XUE XIANG
Author Information
1. 西安交通大学附属第二医院
- Keywords:
Asphyxia;
Prolactin;
Newborn
- From:
Chinese Journal of Contemporary Pediatrics
2003;5(6):505-508
- CountryChina
- Language:Chinese
-
Abstract:
Objective Some research has shown that prolactin (PRL) is closely related to severity of hypoxic-ischemic encephalopathy (HIE). However, the role of maternal and neonatal plasma PRL levels in neonatal asphyxia has not been reported so far. This paper aims at studying the changes of PRL levels in the cord blood, maternal blood and plasna of newborns in neonatal asphyxia. Methods The maternal blood, cord blood and neonatal plasma PRL levels in 25 neonates with asphyxia (asphyxia group) and 20 normal ones (control group) were detected by radioimmunoassay.Results The maternal blood, cord blood and neonatal plasma PRL levels [(362.5 + 127.1), (984.6 + 262.3) and(386.3+216.2) μg/L, respectively] in the asphyxia group were significantly higher than those in the control group[(96.4+26.2), (92.3+ 18.4) and (68.7+7.27) μg/L, respectively] ( P ＜0.01). The maternal blood, cord bloodand neonatal plasma PRL levels [ (445 + 216), (996 + 284) and (412 + 221) μg/L, respectively] in the severe asphyxia groupwere higher than those in the mild asphyxia group [(298 + 102), (612 + 221) and (309 + 19.2) μg/L,respectively] ( P ＜0.01 or 0.05). The cord blood and neonatal plasma PRL levels had a positive correlation both in the mild and the severe asphyxia group ( r = 0.54, r = 0.63 , both P ＜ 0.05 ). The plasma PRL level right after resuscitation was higher than that of the control group ( P ＜0.01). It gradually reduced from the 2nd day after birth,but was higher than that of the control group ( P ＜0.01). The PRL level on the 10th day after birth was not different from that of the control group. Conclusions The PRL levels of neonatal plasma, cord blood and maternal blcod increase in the perinatal asphyxial newborns. The plasma PRL level may be a good marker to evaluate the degree of asphyxia.
