Serum and Cerebrospinal Fluid TNF-α in Children with Acute Leukemia of Various Phases
10.3969/j.issn.1008-8830.2003.04.003
- VernacularTitle:儿童急性白血病不同治疗阶段血液和脑脊液TNF-α变化的研究
- Author:
YU YA-PING
1
;
YANG JI-HONG
;
FU YUAN-FENG
;
SHI PING
;
LIU HAI-NING
;
ZHAI YONG-PING
;
WANG GUO-HONG
Author Information
1. Nanjing General Hospital of Nanjing Command
- Keywords:
Acute leukemia,children;
Central nervous system leukemia;
Tumor necrosis factor-alpha
- From:
Chinese Journal of Contemporary Pediatrics
2003;5(4):297-300
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes and significance of tumor necrosis factor-alpha (TNF-α) in the serum and cerebrospinal fluid (CSF) of children with acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). Methods TNF-α was measured by radioimmunoassay in 31 cases of childhood acute leukemia of various phases. Results Serum TNF-α levels pre-therapy in ALL and AML [(24.35±4.84) pmol/L, (28.65±5.12) pmol/L] were significantly higher than that of control [(11.28±1.69) pmol/L], P<0.01. Right after complete remission (CR), TNF-α decreased [(16.42±2.57) pmol/L, (14.57±3.64) pmol/L] but was higher than that of control (P<0.05). 6, 12, 24, 36 months after CR, serum TNF-α levels in ALL and AML returned to normal. Serum TNF-α increased again and was higher than that of control (P<0.01) when relapsed. CSF TNF-α pre-therapy in ALL and AML [(12.35±1.74) pmol/L, (14.56±1.92) pmol/L] were also significantly higher than that of control [(7.54±0.96) pmol/L] (P<0.01). During CR and continuous CR, CSF TNF-α in ALL and AML patients remained at the level of control (P>0.05). CSF TNF-α level in children with central nervous system leukemia (CNSL) was higher than those without CNSL [(25.62±7.14 pmol/L vs (12.15±0.89) pmol/L], P<0.01. There was a positive correlation between white blood cell count and TNF-α level in the CSF (r=0.942, P<0.05). CSF TNF-α level decreased gradually after intrathecal therapy, but it decreased more slowly than the white blood cells of CSF. Conclusions TNF-α concentration in the serum and CSF may be of great value in reflecting leukemic cell burden, early diagnosis of CNSL and monitoring intrathecal chemotherapy.
