Expression of Bcl-2 and MDR1 Genes in Children with Acute Leukemia
10.3969/j.issn.1008-8830.2003.04.002
- VernacularTitle:儿童急性白血病Bcl-2基因MDR1基因表达及意义
- Author:
HE LI
1
;
HU WAN-RU
;
GUO CHENG-JI
Author Information
1. First Affiliated Hospital China Medical University
- Keywords:
Leukemia;
Bcl-2 gene;
MDR1 gene;
Drug resistance
- From:
Chinese Journal of Contemporary Pediatrics
2003;5(4):294-296,300
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and significance of Bcl-2 and MDR1 genes in children with acute leukemia. Methods The expressions of Bcl-2 and MDR1 genes in 36 cases of acute leukemia and 10 cases of idiopathic thrombocytopenic purpura in the control group were examined by RT-PCR. Results The expressions of Bcl-2 in the incipient group and relapsed group were higher than that of the control group (P<0.05). While in the incipient group and complete remission group, they were lower than that of the relapsed group (P<0.01). The expression of MDR1 gene in the relapsed group was higher than those of control group, incipient group and complete remission group (P<0.01 or 0.05). There was no difference of MDR1 expression between the incipient group and the control group or the complete remission group and the control group (P>0.05). There was no close relationship between the levels of Bcl-2 or MDR1 and clinical features such as gender, age, initial WBC count, the percent of carcinocytes, hepatomegaly, splenomegaly and lymphadenhypertrophy (P>0.05). The relationship between Bcl-2 and MDR1 genes was not significant (rs=0.308, P>0.05). Conclusions Bcl-2 and MDR1 genes were associated with drug resistance by different mechanisms.
