Expression of Hoxd 13 Gene in Children with Congenital Anorectal Malformation
10.3969/j.issn.1008-8830.2003.03.005
- VernacularTitle:先天性肛门直肠畸形Hoxd 13基因表达的研究
- Author:
BAI YU-ZUO
1
;
GAO HONG
;
Wang WEI-LIN
Author Information
1. 中国医科大学附属第二医院
- Keywords:
Anorectal malformation;
Hoxd 13 gene;
RT- PCR;
Gene expression
- From:
Chinese Journal of Contemporary Pediatrics
2003;5(3):201-204
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the Hoxd 13 gene expression in the children with anorectal malformation (CAM)and normal children, and to explore the relationship between Hoxd 13 gene and CAM. Methods Hoxd 13 gene mRNAexpression was detected by RT- PCR in the rectal pouch in both 16 cases of anorectal malformations and 5 normalchildren. Results The expression level of Hoxd 13 gene mRNA was significantly higher in normal children than that inchildren with CAM (0.32+0.26 vs 0.73+0.10), ( P ＜0.01). Conclusions Hoxd 13 gene expression may beinvolved in the pathogenesis of anorectal malformation.
