Relationship Between t(8;21) and Clinical Manifestation, Prognosis of the Children with Acute Myelocytic Leukemia M2
10.3969/j.issn.1008-8830.2003.03.002
- VernacularTitle:t(8;21)与儿童AML-M2临床表现及预后的相关性探讨
- Author:
CHEN JING
1
;
GU LONG-JUN
;
XUE HUI-LIANG
;
PAN CI
;
TANG JING-YAN
;
WANG YAO-PING
Author Information
1. Xinhua Hospital Shanghai Second Medical University
- Keywords:
t(8;
21);
Child;
Acute myelocytic leukemia;
Clinical characteristics;
Prognosis
- From:
Chinese Journal of Contemporary Pediatrics
2003;5(3):189-191
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the influence of t(8;21) on the curative effect and prognosis of children with acutemyelocytic leukemia M2(AML-M2). Methods The clinical characteristics, curative effects, relapse rate, mortality andevent-free survival (EFS) rate of 14 cases of M2 children with t(8;21) and 21 cases of M2 children without t(8;21) wereanalysed. Results There was no statistical difference in age, initial WBC count and clinical characteristics between theM2 patients with t ( 8; 21 ) and without t(8; 21 ) ( P ＞ 0.05 ). The complete remission rate (92.9 % ) in M2 patients witht(8 ;21) was significantly higher than that (57.1% ) of children without t(8;21) ( P ＜ 0.05), while the relapse rateand mortality were of no marked difference between the two groups ( P ＞ 0.05). The overall EFS rate in M2 childrenwith t(8;21) was lower (69.2%) than that (77.8%) of children without t(8;21) ( P ＜0.05). Conclusions Theprognosis of the M2 children with t(8;21) was not better than that of the M2 children without t(8;21). The infuence oft(8;21 ) on the prognosis of M2 might be different from race and region.
