Relationship Between Substance P and Asthma
10.3969/j.issn.1008-8830.2003.03.001
- VernacularTitle:P物质与哮喘的关系
- Author:
SHANG YUN-XIAO
1
;
HAN XIAO-HUA
;
CHENG YUN-WEI
;
ZHAO SU-QIN
;
WEI KE-LUN
Author Information
1. 中国医科大学第二附属医院
- Keywords:
Substance P;
Asthma;
Children;
Guinea pig;
mRNA
- From:
Chinese Journal of Contemporary Pediatrics
2003;5(3):185-188
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the changes of substance P (SP) content in plasma of asthmatic children and in theblood, bronchoalveolar lavage fluid (BALF) and lung tissues of asthmatic guinea pigs and SP mRNA expression, and toinvestigate the relationship between SP and asthma of children. Methods We determined the contents of plasma SP bythe method of immunoassay at the stage of acute attack and clinical remission in 35 children with asthma. On the basis ofasthma model of guinea pigs, we examined the contents of SP in the blood, BALF and lungs. The expression of Spthat of the stage of clinical remission and normal controls ( P ＜0.01). At the stage of clinical remission, the differencethe blood, BALF and lungs were higher than those of normal ones ( P ＜0.01), and the expressions of SP mRNA inlungs were higher ( P ＜0.01). In repeatedly attack group, the SP content of guinea pigs was higher than that of asthmagroup ( P ＜ 0.05), and the expression of SP mRNA in lungs was also higher ( P ＜ 0.01 ). Conclusions SP levelsincreased in asthmatic children and asthmatic guinea pigs, and the expression of SP mRNA was up-regulated in the lungsof asthmatic guinea pigs. They were positive related to the severity of asthma. So SP has close relationship with asthmaand may play a role in the mechanism of asthma.
