Influence of Apolipoprotein E Polymorphism on Serum Lipids in Children
10.3969/j.issn.1008-8830.2001.01.003
- VernacularTitle:载脂蛋白E基因多态性对儿童血脂的影响
- Author:
Xiao ZHANG
1
;
Gen-Rong MAI
;
Zhong-Yan JIANG
Author Information
1. First Affiliated Hospital of Hubei Medical University
- From:
Chinese Journal of Contemporary Pediatrics
2001;3(1):11-13
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine whether APOE influences the serum levels of lipid and lipoprotein. Methods The distribution of apolipoprotein E phenotypes was investigated in 214 children of 2 primary schools (aged 8～12, 116 males and 98 females). Phenotypes of APOE were examined with PCR. Results The E 3/3 phenotype was demonstrated in 69.2%, E 4/3 in 19.1%, E 2/3 in 9.3% and E 4/4 in 2.4%, and E 2/2 and E 2/4 were not detected. The serum levels of total cholesterol and low-density lipoprotein cholesterol and apolipoprotein B were progressively lower in phenotypes E4, E3 and E2. The serum levels of HDL-C, APOA1 and TG showed no statistic difference.Conclusions APOE phenotypes do influence serum lipids of Chinese school children.
