Ferroptosis in glial cells
10.3969/j.issn.1000-4718.2024.11.022
- VernacularTitle:神经胶质细胞的铁死亡
- Author:
Qiuxuan WANG
1
;
Xuyang FENG
;
Yue HUANG
;
Jingxian HAN
;
Xiaoxi LIU
;
Xuezhu ZHANG
Author Information
1. 天津中医药大学第一附属医院,国家中医针灸临床医学研究中心,天津 300381
- Keywords:
ferroptosis;
iron overload;
oxidative stress;
glial cells;
neurons;
inflammation
- From:
Chinese Journal of Pathophysiology
2024;40(11):2166-2172
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a novel form of programmed cell death that relies on the accumulation of intracellular iron ions,causing irreversible damage to cell membranes through extensive lipid peroxidation,ultimately leading to cell death.Ferroptosis is closely associated with various neurodegenerative diseases.The ferroptosis of glial cells can regulate neuronal death by inducing neuroinflammation and affecting oxidative stress,thereby exacerbating the progression of neu-rodegenerative diseases.This review summarizes how ferroptosis occurs in different types of glial cells and its impact on neurons,aiming to deeply understand the effects of glial cell ferroptosis on neurodegenerative diseases and explore the po-tential therapeutic applications of inhibiting this process in treatment.
