Functions and pathophysiological significance of nuclear receptors in psoriasis
10.3969/j.issn.1000-4718.2024.11.021
- VernacularTitle:核受体功能及其在银屑病中的病理生理学意义
- Author:
Chang LI
1
,
2
;
Tingting JIANG
;
Nanping WANG
;
Lei XIAO
Author Information
1. 西安交通大学医学部基础医学院,陕西 西安 710061
2. 大连医科大学医学科学研究院,辽宁 大连 116044
- Keywords:
psoriasis;
nuclear receptor;
gene expression;
transcriptional activity
- From:
Chinese Journal of Pathophysiology
2024;40(11):2160-2165
- CountryChina
- Language:Chinese
-
Abstract:
Psoriasis is a chronic inflammatory skin disease with key pathological features,including hyperpro-liferation and abnormal differentiation of epidermal keratinocytes,infiltration of immune cells,and abnormal angiogene-sis.These pathological processes collectively contribute to the condition's hallmark clinical manifestations of psoriasis,such as erythema,scaling,and pruritus.Nuclear receptors are a class of ligand-dependent transcription factors that form a superfamily.By interacting with their ligands and co-factors,nuclear receptors regulate gene expression and play critical roles in lipid metabolism,glucose metabolism,cholesterol metabolism,embryonic development,and cellular proliferation and differentiation.Nuclear receptors are also involved in the pathogenesis of psoriasis through their regulation of gene ex-pression and cellular functions,particularly in relation to epidermal proliferation and immune-mediated inflammatory re-sponses.This review will provide a brief overview of the roles and mechanisms of nuclear receptors in psoriasis.
