Advances in microglia replacement therapy in neurological disorders
10.3969/j.issn.1000-4718.2024.10.024
- VernacularTitle:小胶质细胞替代治疗在神经系统疾病中的研究进展
- Author:
Tao LI
1
;
Jincheng MENG
;
Zhen ZHANG
;
Danyang LI
Author Information
1. 哈尔滨医科大学附属第一医院病理科,黑龙江 哈尔滨 150007
- Keywords:
microglia;
neuroinflammation;
cell replacement therapy
- From:
Chinese Journal of Pathophysiology
2024;40(10):1975-1979
- CountryChina
- Language:Chinese
-
Abstract:
Microglia are the primary immune cells in the central nervous system.The activation is of microg-lia crucial in neurological injury and neurodegenerative diseases.In recent years,research on microglia-targeted therapies has gained increasing attention.Microglia replacement therapy has shown promising results in treating various neurological diseases.This therapy involves the forced removal of dysfunctional microglia and their replacement with fully differentiated microglia through drug or gene targeting.This article discusses the potential pathophysiological mechanisms and effective therapeutic strategies of microglia replacement therapy in neurological diseases,including Alzheimer's disease and stroke.Moreover,it serves as a reference for the in-depth study of neurobiological mechanisms and treatment of neurological dis-eases.
