Progress in role of lncRNA as ceRNA in regulation of diabetic cardio-myopathy
10.3969/j.issn.1000-4718.2024.10.023
- VernacularTitle:lncRNA作为ceRNA调控糖尿病心肌病的研究进展
- Author:
Xuelin LIU
1
;
Jianting DONG
;
Ruilin WANG
;
Qi ZHANG
;
Guoyin WANG
;
Qian ZHANG
;
Yuemei ZHANG
;
Yongqing CHEN
Author Information
1. 甘肃中医药大学,甘肃 兰州 730000
- Keywords:
diabetic cardiomyopathy;
long noncoding RNA;
competitive endogenous RNA;
ferroptosis;
py-roptosis
- From:
Chinese Journal of Pathophysiology
2024;40(10):1969-1974
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic cardiomyopathy(DCM)is a unique myocardial disease caused by diabetes mellitus,which can increase the risk of heart failure and death,and is one of the main causes of death of diabetes mellitus patients worldwide.Although the research on the pathogenesis of DCM has made great progress,it has not yet been fully clarified.Many studies have shown that long noncoding RNAs(lncRNAs)can interact with microRNAs(miRNAs)as competitive endogenous RNAs(ceRNAs),participate in the regulation of gene expression,and then affect the development of DCM.This article gives an overview of lncRNAs and its biological functions as well as ceRNA hypothesis,and focuses on the role of lncRNAs as ceRNAs in regulating the occurrence and development of DCM.
