Role of vitamin D in non-alcoholic fatty liver disease
10.3969/j.issn.1000-4718.2024.10.022
- VernacularTitle:维生素D在非酒精性脂肪性肝病中的作用
- Author:
Kaiyang LI
1
;
Si SHI
;
Qi ZHAO
;
Mei YANG
Author Information
1. 贵州中医药大学,贵州 贵阳 550002
- Keywords:
non-alcoholic fatty liver disease;
vitamin D;
vitamin D receptor
- From:
Chinese Journal of Pathophysiology
2024;40(10):1963-1968
- CountryChina
- Language:Chinese
-
Abstract:
Non-alcoholic fatty liver disease(NAFLD)is one of the common chronic liver diseases in the world.The molecular mechanism of NAFLD is complex,involving many signal molecules,and the vitamin D(VD)/VDBP/vitamin D receptor(VDR)axis is also involved.VD is a lipid-soluble steroid,which can participate in the regula-tion of lipid metabolism,insulin secretion,immune function,inflammatory response and other biological processes.Stud-ies have shown that VD deficiency is closely related to liver lipid accumulation,inflammation,insulin resistance,oxida-tive stress,intestinal flora imbalance,autophagy,apoptosis,pyroptosis and fibrosis,and plays an important role in the oc-currence and development of NAFLD.This paper reviews the research progress on Vitamin D in recent years in the field of NAFLD,including the physiological characteristics of VD and its role in the NAFLD mechanism,so as to provide referenc-es for the prevention and treatment of NAFLD.
