Progress in application and mechanism of β-hydroxybutyrate supplemen-tation in cardiovascular diseases
10.3969/j.issn.1000-4718.2024.09.024
- VernacularTitle:补充β-羟基丁酸在心血管疾病中应用和机制的研究进展
- Author:
Tingting LI
1
,
2
;
Hui ZHANG
;
Mingchen ZHANG
;
Xiaowen WANG
;
Zhongguang SUN
Author Information
1. 山东第二医科大学康复医学院,山东 潍坊 261053
2. 苏州大学附属第四医院康复医学科,江苏 苏州 215000
- Keywords:
β-hydroxybutyrate;
ketogenic diet;
cardiovascular diseases;
nutritional ketosis
- From:
Chinese Journal of Pathophysiology
2024;40(9):1764-1771
- CountryChina
- Language:Chinese
-
Abstract:
The prevention and treatment of cardiovascular diseases have always been a focus of attention in re-lated fields.This paper discusses the application and mechanism of exogenous and endogenous supplementation with β-hy-droxybutyrate in the prevention and treatment of cardiovascular diseases such as myocardial ischemia,myocardial infarc-tion,diabetic cardiomyopathy,hypertension,myocardial inflammation,hypertrophic cardiomyopathy and heart failure.Exogenous β-hydroxybutyrate supplementation can quickly and directly provide substitute energy for the heart and thus prevent and treat heart injury.The comprehensive effect of exogenous β-hydroxybutyrate supplementation is significantly better than that of endogenous β-hydroxybutyrate.Endogenous fatty acid,obtained through a ketogenic diet,needs to be oxidized to β-hydroxybutyrate in vivo for energy supply,which is greatly influenced by glucose and lipid metabolism under the conditions of the basic disease itself.At present,ketogenic diet is not recommended for use in the prevention and treat-ment of myocardial ischemia or myocardial infarction,and in the treatment of diabetic cardiomyopathy or hypertension.
