Progress in mechanism of ferroptosis FSP1/CoQ10 signaling axis in Al-zheimer disease
10.3969/j.issn.1000-4718.2024.09.023
- VernacularTitle:铁死亡FSP1/CoQ10信号轴在阿尔茨海默病中作用机制的研究进展
- Author:
Yan ZHAO
1
;
Xiaoping HE
;
Yehua ZHANG
;
Xianhui DONG
Author Information
1. 河北中医药大学,河北省心脑血管病中医药防治研究重点实验室,河北 石家庄 050091
- Keywords:
ferroptosis;
FSP1/CoQ10 signaling axis;
Alzheimer disease;
lipid peroxidation
- From:
Chinese Journal of Pathophysiology
2024;40(9):1758-1763
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a form of programmed cell death characterized by iron metabolic imbalance and lipid peroxidation.Alzheimer disease(AD)is a neurodegenerative condition.Studies have shown that lipid peroxidation through ferroptosis plays a significant role in the progression of AD.Ferroptosis suppressor protein 1(FSP1)/coenzyme Q10(CoQ10)signaling axis serves as a crucial regulatory element in the process of lipid peroxidation associated with ferropto-sis.This review explores the mechanisms of the FSP1/CoQ10 signaling axis in AD,aiming to present a novel therapeutic ap-proach for AD treatment.
