Progress in role of humanin in metabolic diseases
10.3969/j.issn.1000-4718.2024.09.020
- VernacularTitle:humanin在代谢性疾病作用中的研究进展
- Author:
Feng JIANG
1
;
Tingting YAO
;
Xuejie YI
;
Haining GAO
Author Information
1. 沈阳体育学院,辽宁 沈阳 110002
- Keywords:
humanin;
metabolic diseases;
type 2 diabetes mellitus;
nonalcoholic fatty liver disease;
athero-sclerosis;
polycystic ovary syndrome
- From:
Chinese Journal of Pathophysiology
2024;40(9):1736-1743
- CountryChina
- Language:Chinese
-
Abstract:
The increasing prevalence of metabolic diseases poses a significant threat to public health,high-lighting the urgent need to identify effective therapeutic targets.Humanin(HN),a 24-amino acid linear peptide synthe-sized from mitochondrial DNA,has been previously acknowledged for its neuroprotective properties.Recent research indi-cates that HN can regulate glucose and lipid metabolism and has shown promise in treating metabolic disorders in animal models using either HN or its analogs.This review outlines the fundamental biological functions and signal transduction mechanisms of HN,and comprehensively evaluates its role and therapeutic potential in type 2 diabetes mellitus,nonalco-holic fatty liver disease,atherosclerosis and polycystic ovary syndrome,aiming to examine the potential of HN as a target for the prevention and treatment of metabolic diseases.
