Research progress in T-cell exhaustion
10.3969/j.issn.1000-4718.2024.08.024
- VernacularTitle:T细胞耗竭的研究进展
- Author:
Yuexia ZHANG
1
,
2
;
Yaozhu PAN
Author Information
1. 青海大学研究生院,青海 西宁 810000
2. 中国人民解放军联勤保障部队第九四〇医院血液科,甘肃 兰州 730000
- Keywords:
T-cell exhaustion;
inhibitory receptor;
cytokine;
immunotherapy
- From:
Chinese Journal of Pathophysiology
2024;40(8):1548-1553
- CountryChina
- Language:Chinese
-
Abstract:
T-cell exhaustion is the loss of T-cell function in patients with chronic infections and cancer.Pro-longed exposure to inflammatory signals or persistent antigens causes T cells to gradually lose their effector function and memory characteristics.Exhausted T cells affect cancer prognosis and the outcome of viral infection,and the severity of ex-haustion has a range of adverse effects on cancer prognosis.The extensive development of tumor immunotherapy has driven current research to understand the mechanism of T-cell exhaustion as well as to optimize tumor immunotherapy regimens by reversing T-cell exhaustion.This article reviews the mechanism of T-cell exhaustion,the characteristics of exhausted T cells,and the reversal of T-cell exhaustion status.
