Effects of high-fat diet on pathology of Alzheimer disease and role of mi-croglia in this process

VernacularTitle:高脂饮食对阿尔茨海默病病变的影响及小胶质细胞在其中的作用
Author: Jing REN ¹ ; Chaojie TAN ; Wenqi ZOU ; Jingyi LIU ; Yu SHENG
Author Information

1. 北华大学药学院,吉林吉林 132013
Keywords: Alzheimer disease; high-fat diet; microglia; lipid metabolism
From: Chinese Journal of Pathophysiology 2024;40(8):1542-1547
CountryChina
Language:Chinese
Abstract: Due to the long pathological process of Alzheimer disease(AD),this paper begins with the time-line of classical pathological events in AD and uses anomalous microglia activation as a starting point to elucidate the role of abnormal lipid metabolism in the pathological process of AD.This includes its influence on microglial pathology and its interactions with the two primary nodes of AD,namely,Amyloid-β and the microtubule-associated protein tau.Using this as a foundation,the paper briefly describes the effects of abnormal lipid metabolism caused by short-term and long-term high-fat diets on the pathological progression of AD and its potential mechanisms,aiming to provide a reference framework for the early intervention of AD.