Progress in role of PI3K/Akt-related signaling pathways in pathophysio-logical mechanism of neural cells
10.3969/j.issn.1000-4718.2024.00.020
- VernacularTitle:PI3K/Akt相关信号通路在神经细胞病理生理机制中的研究进展
- Author:
Guanghong ZENG
1
,
2
;
Tong ZHU
;
Lei ZOU
;
Jie ZHOU
Author Information
1. 甘肃中医药大学第一临床医学院,甘肃 兰州 730000
2. 中国人民解放军联勤保障部队第九四〇医院,甘肃 兰州 730050
- Keywords:
PI3K/Akt signaling pathway;
neural cells;
apoptosis;
autophagy;
oxidative stress
- From:
Chinese Journal of Pathophysiology
2024;40(8):1529-1535
- CountryChina
- Language:Chinese
-
Abstract:
The phosphatidylinositol 3-kinase(PI3K)/protein kinase B(PKB/Akt)signaling pathway plays an important role in various biological processes,including cell growth,proliferation,differentiation,and apoptosis.The PI3K/Akt-related signaling pathways have been extensively studied,and they regulate neural cells to exert different or simi-lar functions.This study reviews the research progress on PI3K/Akt-related signaling pathways in apoptosis,autophagy,oxidative stress,neuroinflammation,and other pathophysiological mechanisms in neural cells.
