Progress in regulation of macrophage function by bitter taste receptors and its mechanism
10.3969/j.issn.1000-4718.2024.08.020
- VernacularTitle:苦味受体调控巨噬细胞功能及其作用机制的研究进展
- Author:
Lele WANG
1
;
Yuzhen FANG
;
Yuqing MA
;
Zixi ZHAO
;
Ruonan MA
;
Xing WANG
;
Yuxin ZHANG
Author Information
1. 中央民族大学药学院,民族医药教育部重点实验室,北京 100081
- Keywords:
bitter taste receptors;
macrophages;
phagocytosis;
chemotaxis;
polarization
- From:
Chinese Journal of Pathophysiology
2024;40(8):1520-1528
- CountryChina
- Language:Chinese
-
Abstract:
Bitter taste receptors,also known as type 2 taste receptors(T2Rs),are found not only in the mouth's taste bud cells but also in various tissues and cells,including macrophages.Macrophages,known for their re-markable plasticity,play a crucial role in regulating innate immunity,managing inflammation,and orchestrating immune responses to antigens,pathogens,and environmental factors.Recently,the study of the expression and function of bitter taste receptors within macrophages has garnered significant interest.This review summarizes the expression levels and dis-tribution characteristics of bitter taste receptors in macrophages and examines their effects on macrophage polarization,phagocytosis,and chemotaxis,as well as their potential molecular mechanisms.The purpose of this review is to provide in-sight and perspectives for research on the regulatory role of T2Rs in macrophage functions.
