Advances in role and mechanisms of Ras-related C3 botulinum toxin sub-strate 1 in pulmonary diseases
10.3969/j.issn.1000-4718.2024.07.024
- VernacularTitle:Ras相关C3肉毒杆菌毒素底物1在肺部疾病中作用及机制的研究进展
- Author:
Wenxia XU
1
;
Yu FANG
Author Information
1. 昆明医科大学第一附属医院麻醉科,云南 昆明 650000
- Keywords:
Ras-related C3 botulinum toxin substrate 1;
lung cancer;
chronic obstructive pulmonary dis-ease;
lung injury;
pulmonary arterial hypertension
- From:
Chinese Journal of Pathophysiology
2024;40(7):1338-1344
- CountryChina
- Language:Chinese
-
Abstract:
Ras-related C3 botulinum toxin substrate 1(RAC1)is a crucial member of the Ras GTPase super-family,exerting an overriding role in cell behaviors such as motility,proliferation and adhesion,and is involved in regu-lating vascular permeability and cellular barrier function.Recently,the significance of RAC1 in the etiology and progres-sion of various pulmonary disorders has garnered increasing attention,which sheds light on lung disease study.In this re-view,we introduce the characteristics of RAC1 systematically and recapitulate its effects and molecular mechanisms in the context of lung tumors,chronic obstructive pulmonary disease,lung injury and pulmonary arterial hypertension,hoping to provide new insights for future pulmonary disease treatment.
