Extracellular matrix:a new therapeutic target for local tissue damage caused by snake bites

VernacularTitle:细胞外基质:毒蛇咬伤致局部组织损伤的治疗新靶点
Author: Yumei LI ¹ ; Yue YANG ; Jun YI ; Zhangren YAN ; Wanchun WANG ; De-Gang DONG
Author Information

1. 江西中医药大学研究生院,江西南昌 330004
Keywords: snake bites; extracellular matrix; local tissue damage; hemorrhage; myotoxicity
From: Chinese Journal of Pathophysiology 2024;40(7):1324-1330
CountryChina
Language:Chinese
Abstract: Snake bites are characterized by acute onset,rapid changes in condition,and high disability and mortality rates.The effects of snake venom on the human body are divided into systemic and local toxic effects.The popu-larity of antivenom has greatly reduced the mortality of snake bites,but local tissue damage and permanent dysfunction are still problems to be solved urgently.Studies have found that snake venom metalloproteinases,hyaluronidases,phospholi-pases and other venoms participate in a variety of local pathological effects by interfering with the degradation and remodel-ing of extracellular matrix(ECM).This article reviews the mechanism of ECM in the development of local tissue damage caused by snake bites,in order to find effective therapeutic targets and provide reference and ideas for the clinical research and prevention of local tissue damage caused by snake bites.