Preventive and intervention effect of bioactive compounds on gestational diabetes mellitus based on endoplasmic reticulum stress pathway
10.3969/j.issn.1000-4718.2024.07.021
- VernacularTitle:内质网应激在妊娠期糖尿病中的作用及生物活性成分防治的研究进展
- Author:
Nannan HU
1
;
Chengao ZHAO
;
Qin GAO
;
Qingfeng ZHAI
Author Information
1. 山东第二医科大学公共卫生学院,山东 潍坊 261053
- Keywords:
gestational diabetes mellitus;
endoplasmic reticulum stress;
insulin resistance;
β-cell impair-ment;
bioactive compounds
- From:
Chinese Journal of Pathophysiology
2024;40(7):1316-1323
- CountryChina
- Language:Chinese
-
Abstract:
The global prevalence of gestational diabetes mellitus(GDM)is approximately 13.4%and is ex-pected to increase annually.However,the precise mechanism behind GDM remains to be established.Increasing evi-dence suggests that insulin resistance(IR)and β-cell impairment are key factors in the pathogenesis of GDM.Endoplas-mic reticulum stress(ERS)is characterized by the activation of the unfolded protein response through three key endoplas-mic reticulum transmembrane proteins:protein kinase RNA-like endoplasmic reticulum kinase(PERK),inositol-requiring enzyme 1α(IRE1α),and activating transcription factor 6(ATF6).ERS is implicated in IR in adipose tissue,liver,skeletal muscle,and placenta,and also plays a crucial role in β-cell impairment through processes such as apopto-sis,pyroptosis,and autophagy.Therefore,targeting ERS could be a potential therapeutic approach for the prevention and treatment of GDM.This review explores the potential role of ERS in IR and β-cell dysfunction in GDM,and provides evi-dence for the preventive and intervention effects of bioactive compounds on GDM based on the ERS pathway.This aims to enhance our understanding of the molecular pathological basis of GDM and offer new strategies for its prevention and treat-ment.
