Comparison of two tools for risk assessment of delayed chemotherapy-related nausea and vomiting after arterial chemoembolization in patients with primary liver cancer
10.3760/cma.j.cn115682-20210610-02568
- VernacularTitle:两种工具在原发性肝癌患者经动脉化疗栓塞术后延迟性化疗相关恶心呕吐风险评估中的比较
- Author:
Shanshan ZHOU
1
;
Hongmei DING
;
Xueping XU
;
Yali SUN
;
Zhengjing LI
Author Information
1. 江苏省肿瘤医院介入治疗科，南京 210009
- Keywords:
Liver neoplasms;
Nausea;
Vomiting;
Chemoembolization;
Risk assessment
- From:
Chinese Journal of Modern Nursing
2022;28(4):452-457
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the predictive value of the Delayed Chemotherapy Induced Nausea and Vomiting Risk Index (DCINV-RI) and the Chemotherapy Induced Nausea and Vomiting Risk Prediction Tool (CINV-RPT) in the risk assessment of delayed chemotherapy induced nausea and vomiting (DCINV) after arterial chemoembolization in patients with primary liver cancer.Methods:From May 2020 to May 2021, convenience sampling was used to select 212 primary liver cancer patients with arterial chemoembolization in the Department of Intervention Therapy of Jiangsu Cancer Hospital as the research object. The patients were divided into the control group ( n=80) and the DCIVN group ( n=132) according to the occurrence of DCIVN. DCINV risk assessment of patients was performed using DCINV-RI and CINV-RPT. Area under the receiver operating characteristic curve ( AUC) , sensitivity, specificity, and Youden index were used to compare the predictive value of the two tools. Results:Among the 212 patients with primary liver cancer, 62.26% (132/212) had grade 2 or above DCINV. When using the two tools for DCINV risk assessment, the scores of patients in the DCINV group were higher than those in the control group, and the difference was statistically significant ( P<0.01) . The AUC for the DCINV-RI score was 0.852. When the total score was 20.500 points, the sensitivity, specificity, and Youden index were 0.838, 0.765, and 0.603 respectively ( P<0.01) , and the predictive value of DCINV-RI was the greatest at this point. The AUC of the CINV-RPT score was 0.924. When the total score was 12.500, the sensitivity, specificity and Youden index were 0.863, 0.841, and 0.703 respectively ( P<0.01) , and the predictive value of CINV-RPT was the greatest at this point. The AUC, sensitivity, specificity and Youden index of CINV-RPT score were higher than those of DCINV-RI score, and the difference was significantly statistical. Conclusions:The incidence of DCINV in patients with primary liver cancer after arterial chemoembolization is at a high level. Both DCINV-RI and CINV-RPT can effectively predict the risk of DCINV in patients with primary liver cancer after arterial chemoembolization, but the predictive value of CINV-RPT is higher than that of DCINV-RI.
