Progress in bromodomain-containing protein 4 in pathogenesis of cardiovascular diseases
10.3969/j.issn.1000-4718.2024.06.022
- VernacularTitle:含溴结构域蛋白4在心血管疾病发病机制中的研究进展
- Author:
Lei HE
1
;
Quanbin DONG
;
Juxiang LI
Author Information
1. 南昌大学第二附属医院心血管内科,江西 南昌 330006
- Keywords:
cardiovascular disease;
bromodomain-containing protein 4;
BRD4 inhibitor;
pathogenesis
- From:
Chinese Journal of Pathophysiology
2024;40(6):1141-1146
- CountryChina
- Language:Chinese
-
Abstract:
Bromodomain-containing protein 4(BRD4),a pivotal member of the bromodomain and extra-ter-minal domain(BET)family,is integral to the regulation of vital biological processes,including the cell cycle and gene ex-pression.Studies have identified extensive expression of BRD4 in cardiomyocytes and its influence on various signaling pathways.The dysregulation of BRD4 leads to significant alterations in these pathways,culminating in pathological states such as myocardial inflammation,fibrosis,oxidative stress,and hypertrophy.These changes are instrumental in the onset and progression of cardiovascular diseases.This review summarizes the advances in research on BRD4 and its inhibitors in the context of cardiovascular diseases,with a focus on providing insights for precise therapeutic interventions.
