Current progress in role of circular RNA in stroke
10.3969/j.issn.1000-4718.2024.06.018
- VernacularTitle:环状RNA对脑卒中作用的研究进展
- Author:
Di LÜ
1
;
Hengqian DUAN
;
Zhujun ZHUANG
;
Peng CHEN
;
Renhua YANG
;
Zhiqiang SHEN
;
Bo HE
Author Information
1. 昆明医科大学药学院暨云南省天然药物药理重点实验室,云南 昆明 650500
- Keywords:
circular RNA;
stroke;
oxidative stress;
autophagy;
apoptosis;
inflammation;
epigenetics
- From:
Chinese Journal of Pathophysiology
2024;40(6):1114-1121
- CountryChina
- Language:Chinese
-
Abstract:
Stroke is a cerebrovascular disease characterized by high rates of disability,recurrence and mortal-ity.It results primarily from cerebrovascular rupture or transient/permanent occlusion.Due to the complex pathological mechanism of stroke and the lack of early-stage biomarkers,effective treatment options remain limited.Circular RNAs(circRNAs)are stable and conserved endogenous long noncoding RNA that regulate the pathological process of stroke,in-cluding oxidative stress,inflammation,apoptosis and autophagy.In addition,the regulatory roles of circRNAs in stroke include ceRNA,DNA methylation and histone modification.This review provides a comprehensive overview of circRNA biogenesis,major functions and characteristics.Furthermore,it presents the latest research findings on circRNAs in the context of stroke pathology,with the aim of providing new insights and potential approaches for unraveling the underlying mechanism,diagnosis and treatment of such diseases.
