Different exercise intensity alleviates fear memory generalization in PTSD mice by promoting adiponectin mediated adult hippocampal neurogene-sis
10.3969/j.issn.1000-4718.2024.06.007
- VernacularTitle:不同强度运动改善PTSD小鼠恐惧记忆泛化及促海马神经再生效应研究
- Author:
Shuo JIN
1
;
Xiaoxiao ZHANG
;
Chenxuan JI
;
Lina SUN
Author Information
1. 北京师范大学体育与运动学院,北京 100875
- Keywords:
exercise intensity;
adiponectin;
adult hippocampal neurogenesis;
post-traumatic stress disorder;
fear memory generalization
- From:
Chinese Journal of Pathophysiology
2024;40(6):1017-1024
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To explore the intensity-dependent effects of exercises to alleviate fear memory generaliza-tion in post-traumatic stress disorder(PTSD)and the underlying mechanism.METHODS:Male C57 BL/6J mice were randomly divided into the control group,PTSD group,high-intensity exercise(PTSD-High)group,and low-intensity exer-cise(PTSD-Low)group.PTSD model were created via using a combination of conditioned foot shock(CF)and single-pro-longed stress(SPS).The contextual fear test was used to test the mice's ability to discriminate safety situations from fear condition.Immunofluorescence observed and quantified the newborn immature neurons in the DG area of the mice's hippo-campus.ELISA was used to determine the secretion level of serum tissue adiponectin.RESULTS:(1)The immobility times for the PTSD-High and Control groups were significantly lower than those of the PTSD group.(2)Immunofluores-cence analysis showed that the cell density,dendritic branching points and length of newborn immature neurons were ele-vated in High and Low groups compared to the PTSD group.(3)Adiponectin levels in the serum of the control and PTSD-High group were significantly higher than those in the PTSD group and PTSD-Low group.CONCLUSION:Fear memory establishment in PTSD mice is associated with decreased hippocampal neurogenesis.High-intensity exercise ameliorated fear memory by enhancing adiponectin secretion and promoting hippocampal neurogenesis.High-intensity exercise exerted better improvement of brain functions to PTSD model.
