Application of single-cell RNA sequencing in pulmonary infection by pathogenic microorganisms

VernacularTitle:单细胞转录组测序在病原微生物肺部感染研究中的应用
Author: Jiajia HUANG ¹ ; Chuwen WANG ; Ying LIU ; Yingying ZHANG ; Ran CHEN ; Guoqing QIAN
Author Information

1. 宁波大学附属第一医院,浙江宁波 315000
Keywords: single-cell RNA sequencing; pulmonary infection; pathogenic microorganisms
From: Chinese Journal of Pathophysiology 2024;40(5):950-955
CountryChina
Language:Chinese
Abstract: Pulmonary infection by pathogenic microorganisms is a common disease of the respiratory system with high mortality and poor prognosis,but its pathogenesis remains unclear.In recent years,single-cell RNA sequencing(scRNA-seq)has been widely used in the study of lung infection to provide an atlas of immune cells of patients,identify new immune cell subsets,analyze differential expression genes,reveal pathways related to inflammatory immune pathways in pathogenic microbial infection,monitor the levels of cytokines,and identify novel biomarkers of lung infection.There-fore,this paper presents a review of the application of scRNA-seq in pulmonary infection by pathogenic microorganisms.