Progress in role of m6A modification in non-small-cell lung cancer

VernacularTitle:m6A修饰在非小细胞肺癌中作用的研究进展
Author: Naixiang ZHANG ¹ ; Jiangxia LIN ; Jinzhi PENG ; Junwei ZENG ; Yuanshou CHEN ; Huan JIN
Author Information

1. 遵义医科大学生理学教研室,贵州遵义 563000
Keywords: non-small-cell lung cancer; m6A modification; methyltransferases; demethylases
From: Chinese Journal of Pathophysiology 2024;40(5):917-923
CountryChina
Language:Chinese
Abstract: N6-methyladenosine(m6A)denotes the addition of a methyl group to the sixth nitrogen atom of ade-nosine,a common occurrence in eukaryotic RNA.The m6A modifications govern RNA splicing,translocation,stability,and translation into proteins.The RNA methyltransferases,like methyltransferase-like protein 3(METTL3),METTL14,and Wilms'tumor 1-associated protein(WTAP),are responsible for these modifications,while the removal process in-volves demethylases,specifically fat mass and obesity-associated protein(FTO)and ALKB homolog 5(ALKBH5).Recog-nition of these modifications is facilitated by m6A-binding proteins,such as YTH family proteins and insulin-like growth factor 2 mRNA-binding proteins(IGF2BPs).The m6A modification regulators are involved in the onset and progression of non-small-cell lung cancer through multiple mechanisms.This review concentrates on the biological functions and molecu-lar mechanisms of m6A modification-related regulatory factors in the malignant progression of non-small-cell lung cancer.