A Case of Rapidly Progressive Kaposi's Sarcoma Induced by Systemic Corticosteroid Therapy.
- Author:
Ho Yeol LEE
1
;
Cheong Ha WOO
;
Hai Jin PARK
;
Sik HAW
Author Information
1. Department of Dermatology, Ilsan Paik Hospital, College of Medicine, Inje University, Goyang, Korea. hawsik@paik.ac.kr
- Publication Type:Case Report
- Keywords:
Kaposi sarcoma;
Iatrogenic disease;
Glucocorticoids
- MeSH:
Aged, 80 and over;
Angioplasty;
Arterial Occlusive Diseases;
Biopsy;
Endothelial Cells;
Glucocorticoids;
Humans;
Iatrogenic Disease;
Leg;
Prednisolone;
Pulmonary Disease, Chronic Obstructive;
Sarcoma, Kaposi*;
Skin;
Transplants;
Vascular Neoplasms
- From:Korean Journal of Dermatology
2017;55(9):606-609
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Kaposi's sarcoma (KS) is a vascular neoplasm originating from vascular and lymphatic endothelial cells. Iatrogenic KS mainly develops in organ transplant patients or after receiving immunosuppressive therapy. An 81-year-old man presented with multiple dark-purplish nodules, plaques, and patches on the right leg for 3 weeks. Previously, the patient was treated with prednisolone 10∼30 mg/day for chronic obstructive pulmonary disease for 3 months, and percutaneous transluminal angioplasty was performed 1 month previously for the treatment of peripheral arterial occlusive disease. A biopsy specimen of the nodule showed closely packed spindle cells forming slit-like vascular structures, which were consistent with KS. Despite the dosage reduction of prednisolone for treatment, the skin lesions progressed aggressively throughout the entire body, and the patient died after 5 months. We report a case of iatrogenic prednisolone-associated KS rapidly progressing to the entire body shortly thereafter.
