A Case of Primary Cutaneous Anaplastic Large Cell Lymphoma on Palm.
- Author:
Byeong Su KIM
1
;
Moon Hyung YOU
;
Joon Goon KIM
;
Yeon Woong KIM
;
Dong Hoon SHIN
;
Jong Soo CHOI
Author Information
1. Department of Dermatology, College of Medicine, Yeungnam University, Daegu, Korea. dhshin@med.yu.ac.kr
- Publication Type:Case Report
- Keywords:
Anaplastic large cell lymphoma;
Cutaneous lymphoma;
Methotrexate
- MeSH:
Adult;
Antigens, CD30;
Dermis;
Diagnosis;
Extremities;
Female;
Humans;
Injections, Intralesional;
Lymphocytes;
Lymphoma;
Lymphoma, Large-Cell, Anaplastic;
Lymphoma, Primary Cutaneous Anaplastic Large Cell*;
Methotrexate;
Mucin-1;
Phosphotransferases;
Skin;
Ulcer
- From:Korean Journal of Dermatology
2017;55(9):610-614
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Primary cutaneous anaplastic large cell lymphoma (PCALCL) is a rare primary cutaneous lymphoma that is predominantly composed of large lymphoid cells that express the CD30 antigen. The skin lesion of PCALCL is usually single, ulcerative, and located on the trunk or extremities and rarely the palm. A 25-year-old woman presented with a plaque on the left palm for 20 days. The plaque was walnut-sized and purple to gray colored with erosion in the center. Histopathologic examination showed infiltration of large atypical cells in the dermis. The large tumor cells showed positivity for CD3, CD4, and CD30 and negativity for CD8, CD20, epithelial membrane antigen, and anaplastic lymphoma kinase. PET-CT showed no other hypermetabolic lesion except that on the left palm, and we finally arrived at a diagnosis of PCALCL. The patient was treated with an intralesional injection of methotrexate (25 mg/mL, 0.45 cc). After 3 months of treatment, the walnut-sized plaque had disappeared and a peripheral hyperpigmented patch remained.
